Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype

Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype

Abstract Background During embryonic development Wnt family members and bone morphogenetic proteins (BMPs) cooperatively induce epithelial-mesenchymal transition (EMT) in the neural crest. Wnt and BMPs are reactivated during malignant transformation in melanoma. We previously demonstrated that the B...

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Bibliographic Details
Main Authors: Tobias Sinnberg, Mitchell P. Levesque, Jelena Krochmann, Phil F. Cheng, Kristian Ikenberg, Francisco Meraz-Torres, Heike Niessner, Claus Garbe, Christian Busch
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
Melanoma
Epithelial mesenchymal transition
Wnt3a
β-catenin
Metastasis
Invasion
Online Access:http://link.springer.com/article/10.1186/s12943-018-0773-5

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http://link.springer.com/article/10.1186/s12943-018-0773-5

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