A Combined Model of Human iPSC‐Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome

A Combined Model of Human iPSC‐Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome

Abstract Mitochondrial DNA depletion syndrome (MDS) is a group of severe inherited disorders caused by mutations in genes, such as deoxyribonucleoside kinase (DGUOK). A great majority of DGUOK mutant MDS patients develop iron overload progressing to severe liver failure. However, the pathological me...

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Bibliographic Details
Main Authors: Jingyi Guo, Lifan Duan, Xueying He, Shengbiao Li, Yi Wu, Ge Xiang, Feixiang Bao, Liang Yang, Hongyan Shi, Mi Gao, Lingjun Zheng, Huili Hu, Xingguo Liu
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Advanced Science
Subjects:
ferroptosis
induced pluripotent stem cells
mitochondria
mitochondrial DNA
N‐acetylcysteine
Online Access:https://doi.org/10.1002/advs.202004680

Internet

https://doi.org/10.1002/advs.202004680

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