Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI

Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI

Abstract Background Preclinical studies have identified both NAD+ and sirtuin augmentation as potential strategies for the prevention and treatment of AKI. Nicotinamide riboside (NR) is a NAD+ precursor vitamin and pterostilbene (PT) is potent sirtuin activator found in blueberries. Here, we tested...

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Bibliographic Details
Main Authors: Petra Simic, Xavier Fernando Vela Parada, Samir M. Parikh, Ryan Dellinger, Leonard P. Guarente, Eugene P. Rhee
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Nephrology
Subjects:
Acute kidney injury
NAD+
Nicotinamide riboside
Pterostilbene
Safety study
Online Access:http://link.springer.com/article/10.1186/s12882-020-02006-1

Internet

http://link.springer.com/article/10.1186/s12882-020-02006-1

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