Virulent infection of outbred Hartley guinea pigs with recombinant Pichinde virus as a surrogate small animal model for human Lassa fever

Arenaviruses, such as Lassa virus (LASV), can cause severe and fatal hemorrhagic fevers (e.g., Lassa fever, LF) in humans with no vaccines or therapeutics. Research on arenavirus-induced hemorrhagic fevers (AHFs) has been hampered by the highly virulent nature of these viral pathogens, which require...

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Bibliographic Details
Main Authors: Shuiyun Lan, Wun-Ju Shieh, Qinfeng Huang, Sherif R. Zaki, Yuying Liang, Hinh Ly
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Virulence
Subjects:
Online Access:http://dx.doi.org/10.1080/21505594.2020.1809328