Differences in tumor microenvironments between primary lung tumors and brain metastases in lung cancer patients: therapeutic implications for immune checkpoint inhibitors

Differences in tumor microenvironments between primary lung tumors and brain metastases in lung cancer patients: therapeutic implications for immune checkpoint inhibitors

Abstract Background We aimed to compare intra- and extracranial responses to immune checkpoint inhibitors (ICIs) in lung cancer with brain metastases (BM), and to explore tumor microenvironments of the brain and lungs focusing on the programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-...

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Bibliographic Details
Main Authors: Ryul Kim, Bhumsuk Keam, Sehui Kim, Miso Kim, Se Hyun Kim, Jin Wook Kim, Yu Jung Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Jong Seok Lee, Dae Seog Heo
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Cancer
Subjects:
Immunotherapy
Lung cancer
Brain metastasis
PD-1
PD-L1
Online Access:http://link.springer.com/article/10.1186/s12885-018-5214-8

Internet

http://link.springer.com/article/10.1186/s12885-018-5214-8

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