Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4+ T Effector and Regulatory T Cells in Cutaneous Leishmaniasis

Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4+ T Effector and Regulatory T Cells in Cutaneous Leishmaniasis

Cutaneous Leishmaniasis (CL) affects up to one million people every year and treatments are costly and toxic. The regulation of the host immune response is complex and the knowledge of how CD4+ T cells are activated and maintained during Leishmania infection is still limited. Current therapies aim t...

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Bibliographic Details
Main Authors: Rafael de Freitas e Silva, Rosa Isela Gálvez, Valéria Rego Alves Pereira, Maria Edileuza Felinto de Brito, Siew Ling Choy, Hannelore Lotter, Lidia Bosurgi, Thomas Jacobs
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
leishmaniasis
CD4 T cell
co-inhibitory receptors
PD-1 (CD279)
PD-L1 (B7-H1 CD274)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.574491/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.574491/full

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