cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool

cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool

It is widely accepted that cAMP regulates gene transcription principally by activating the protein kinase A (PKA)-targeted transcription factors. Here, we show that cAMP enhances the generation of 5-hydroxymethylcytosine (5hmC) in multiple cell types. 5hmC is converted from 5-methylcytosine (5mC) by...

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Bibliographic Details
Main Authors: Vladimir Camarena, David W Sant, Tyler C Huff, Sushmita Mustafi, Ryan K Muir, Allegra T Aron, Christopher J Chang, Adam R Renslo, Paula V Monje, Gaofeng Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
cAMP
labile Fe(II)
5-hydroxymethylcytosine
GPCR
RapGEF2
PKA
Online Access:https://elifesciences.org/articles/29750

Internet

https://elifesciences.org/articles/29750

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