Solution‐Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies

Solution‐Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies

Abstract Amyloid β‐peptides (Aβ) play a major role in the pathogenesis of Alzheimer's disease. Therefore, numerous monoclonal antibodies against Aβ have been developed for basic and clinical research. The present study applied fluorescence based analytical ultracentrifugation and microscale the...

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Bibliographic Details
Main Authors: Tao Zhang, Dr. Luitgard Nagel‐Steger, Prof. Dr. Dieter Willbold
Format: Article
Language:English
Published: Wiley-VCH 2019-07-01
Series:ChemistryOpen
Subjects:
amyloid β-peptides
analytical ultracentrifugation
microscale thermophoresis
monoclonal antibodies
protein-protein interactions
Online Access:https://doi.org/10.1002/open.201900167

Internet

https://doi.org/10.1002/open.201900167

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