Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy[S]

Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy[S]

Defective autophagy has been linked to lipotoxicity in several cellular models. We aimed to investigate autophagy in lipid-stimulated hepatoma (Huh7) cells and tested whether 4-phenyl butyric acid (4-PBA), a chemical chaperone, has a beneficial role in hepatic fat accumulation and lipotoxicity. We r...

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Bibliographic Details
Main Authors: Ashraf U. Nissar, Love Sharma, Malik A. Mudasir, Lone A. Nazir, Sheikh A. Umar, Parduman R. Sharma, Ram A. Vishwakarma, Sheikh A. Tasduq
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Journal of Lipid Research
Subjects:
lipid droplet
Atg7
cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520339560

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http://www.sciencedirect.com/science/article/pii/S0022227520339560

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