Functional analysis of connexin-32 mutants associated with X-linked dominant Charcot-Marie-Tooth disease

Functional analysis of connexin-32 mutants associated with X-linked dominant Charcot-Marie-Tooth disease

To investigate the pathogenic role of connexin-32 (Cx32) mutation in X-linked dominant Charcot-Marie-Tooth disease (CMTX), dual whole-cell voltage-clamp recordings and tracer coupling were performed to investigate functional properties of wild-type and 22 CMTX mutant Cx32 proteins expressed in N2A c...

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Bibliographic Details
Main Authors: Hung-Li Wang, Wen-Teng Chang, Tu-Hsueh Yeh, Tony Wu, Mei-Shin Chen, Ching-Yi Wu
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neurobiology of Disease
Subjects:
Connexin-32
X-linked dominant Charcot-Marie-Tooth disease
Gap junction
N2A cells
Junctional conductance
Tracer coupling
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002432

Internet

http://www.sciencedirect.com/science/article/pii/S0969996103002432

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