Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity

Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity

Abstract Amyotrophic Lateral Sclerosis (ALS) is a lethal neurodegenerative disorder that primarily affects motor neurons. Dominant mutations in the RNA binding protein Fused in Sarcoma (FUS) have been identified as causative factors of ALS. Mutation, R495X, results in a premature stop codon and indu...

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Bibliographic Details
Main Authors: Tadashi Nakaya, Manolis Maragkakis
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Mitochondria Shortening
RX821002 Binding
Aggressive Disease Phenotype
Targetome
Mitochondria Size
Online Access:https://doi.org/10.1038/s41598-018-33964-0

Internet

https://doi.org/10.1038/s41598-018-33964-0

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