AhR/miR-23a-3p/PKCα axis contributes to memory deficits in ovariectomized and normal aging female mice

AhR/miR-23a-3p/PKCα axis contributes to memory deficits in ovariectomized and normal aging female mice

The mechanism of estrogen deficiency-induced cognitive impairment is still not fully elucidated. In this study, we assessed the effect of microRNA (miRNA) on the memory of long-term estrogen-deficient mice after ovariectomy (OVX) and normal aging. We observed that 5-month OVX and 22-month-old normal...

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Bibliographic Details
Main Authors: Shuai Zhang, Xiaobin An, Siyu Huang, Lu Zeng, Yi Xu, Dan Su, Yang Qu, Xin Tang, Jing Ma, Junkai Yang, Jing Ai
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
miR-23a-3p
PKCα
aryl hydrocarbon receptor
memory
OVX
aging
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000500

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http://www.sciencedirect.com/science/article/pii/S2162253121000500

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