Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38α Kinase
Ovarian cancer is sensitive to chemotherapy with platinum compounds; however, the therapy success rate is significantly lowered by a high incidence of recurrence and by the acquisition of drug resistance. These negative outcomes mainly depend on altered apoptotic and drug resistance pathways, determ...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2012-01-01
|
Series: | Journal of Oncology |
Online Access: | http://dx.doi.org/10.1155/2012/382159 |
id |
doaj-cb8bb27f5fa34bd585bb6a4ed8ac2caa |
---|---|
record_format |
Article |
spelling |
doaj-cb8bb27f5fa34bd585bb6a4ed8ac2caa2020-11-24T23:53:27ZengHindawi LimitedJournal of Oncology1687-84501687-84692012-01-01201210.1155/2012/382159382159Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38α KinaseValentina Grossi0Cristiano Simone1Laboratory of Signal-dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario NegriSud 66030, Santa Maria Imbaro, ItalyLaboratory of Signal-dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario NegriSud 66030, Santa Maria Imbaro, ItalyOvarian cancer is sensitive to chemotherapy with platinum compounds; however, the therapy success rate is significantly lowered by a high incidence of recurrence and by the acquisition of drug resistance. These negative outcomes mainly depend on altered apoptotic and drug resistance pathways, determining the need for the design of new therapeutic strategies to improve patient survival. This challenge has become even more critical because it has been recognized that hindering uncontrolled cell growth is not sufficient as the only curative approach. In fact, while current therapies are mostly conceived to impair survival of highly proliferating cells, several lines of research are now focusing on cancer-specific features to specifically target malignant cells with the aim of avoiding drug resistance and reducing adverse effects. Recently, great interest has been generated by the identification of metabolic reprogramming mechanisms occurring in cancer cells, such as the increase in glycolysis levels. In this light, pharmacologic manipulation of relevant pathways involved in cancer-specific metabolism and drug resistance could prove an effective approach to treat ovarian cancer patients.http://dx.doi.org/10.1155/2012/382159 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Valentina Grossi Cristiano Simone |
spellingShingle |
Valentina Grossi Cristiano Simone Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38α Kinase Journal of Oncology |
author_facet |
Valentina Grossi Cristiano Simone |
author_sort |
Valentina Grossi |
title |
Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38α Kinase |
title_short |
Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38α Kinase |
title_full |
Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38α Kinase |
title_fullStr |
Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38α Kinase |
title_full_unstemmed |
Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38α Kinase |
title_sort |
special agents hunting down women silent killer: the emerging role of the p38α kinase |
publisher |
Hindawi Limited |
series |
Journal of Oncology |
issn |
1687-8450 1687-8469 |
publishDate |
2012-01-01 |
description |
Ovarian cancer is sensitive to chemotherapy with platinum compounds; however, the therapy success rate is significantly lowered by a high incidence of recurrence and by the acquisition of drug resistance. These negative outcomes mainly depend on altered apoptotic and drug resistance pathways, determining the need for the design of new therapeutic strategies to improve patient survival. This challenge has become even more critical because it has been recognized that hindering uncontrolled cell growth is not sufficient as the only curative approach. In fact, while current therapies are mostly conceived to impair survival of highly proliferating cells, several lines of research are now focusing on cancer-specific features to specifically target malignant cells with the aim of avoiding drug resistance and reducing adverse effects. Recently, great interest has been generated by the identification of metabolic reprogramming mechanisms occurring in cancer cells, such as the increase in glycolysis levels. In this light, pharmacologic manipulation of relevant pathways involved in cancer-specific metabolism and drug resistance could prove an effective approach to treat ovarian cancer patients. |
url |
http://dx.doi.org/10.1155/2012/382159 |
work_keys_str_mv |
AT valentinagrossi specialagentshuntingdownwomensilentkillertheemergingroleofthep38akinase AT cristianosimone specialagentshuntingdownwomensilentkillertheemergingroleofthep38akinase |
_version_ |
1725469643948163072 |