Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

Abstract Background Progressive neuron loss in the frontal and temporal lobes of the cerebral cortex typifies frontotemporal lobar degeneration (FTLD). FTLD sub types are classified on the basis of neuronal aggregated protein deposits, typically containing either aberrantly phosphorylated TDP-43 or...

Full description

Bibliographic Details
Main Authors: Laura M. Taylor, Pamela J. McMillan, Nicole F. Liachko, Timothy J. Strovas, Bernardino Ghetti, Thomas D. Bird, C. Dirk Keene, Brian C. Kraemer
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Neurodegeneration
Subjects:
Tau
Online Access:http://link.springer.com/article/10.1186/s13024-018-0237-9