Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels

Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels

Ataxin-2 (ATXN2) polyglutamine domain expansions of large size result in an autosomal dominantly inherited multi-system-atrophy of the nervous system named spinocerebellar ataxia type 2 (SCA2), while expansions of intermediate size act as polygenic risk factors for motor neuron disease (ALS and FTLD...

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Bibliographic Details
Main Authors: Nesli Ece Sen, Jessica Drost, Suzana Gispert, Sylvia Torres-Odio, Ewa Damrath, Michael Klinkenberg, Hamid Hamzeiy, Gülden Akdal, Halil Güllüoğlu, A. Nazlı Başak, Georg Auburger
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Mitochondrial dynamics
Autophagy
Ribosomal translation
RNA processing
Parkinsonism
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302182

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http://www.sciencedirect.com/science/article/pii/S0969996116302182

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