The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.

The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.

One of the major causes of chemotherapy failure in cancer treatment is multidrug resistance (MDR) which is mediated by the ABCB1/P-glycoprotein. Previously, through the use of an extensive screening process, we found that vardenafil, a phosphodiesterase 5 (PDE-5) inhibitor significantly reverses MDR...

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Bibliographic Details
Main Authors: Pei-Rong Ding, Amit K Tiwari, Shinobu Ohnuma, Jeferson W K K Lee, Xin An, Chun-Ling Dai, Qi-Si Lu, Satyakam Singh, Dong-Hua Yang, Tanaji T Talele, Suresh V Ambudkar, Zhe-Sheng Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3084276?pdf=render

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http://europepmc.org/articles/PMC3084276?pdf=render

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