Effects of Anonaine on Dopamine Biosynthesis and L-DOPA-Induced Cytotoxicity in PC12 Cells

Effects of Anonaine on Dopamine Biosynthesis and L-DOPA-Induced Cytotoxicity in PC12 Cells

The effects of anonaine, an aporphine isoquinoline alkaloid, on dopaminebiosynthesis and L-DOPA-induced cytotoxicity in PC12 cells were investigated. Anonaineat concentration ranges of 0.01-0.2 μM showed a significant inhibition of dopaminecontent at 24 h, with an IC50 value of 0.05 μM. Anonai...

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Bibliographic Details
Main Authors: Myung Koo Lee, Sung Cil Lim, Shi Yong Ryu, Young Kyoon Kim, Chun Mei Jin, Jae Joon Lee
Format: Article
Language:English
Published: MDPI AG 2008-02-01
Series:Molecules
Subjects:
Anonaine
Dopamine biosynthesis
L-DOPA-induced cytotoxicity
PC12 cells.
Online Access:http://www.mdpi.com/1420-3049/13/2/475/

Internet

http://www.mdpi.com/1420-3049/13/2/475/

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