The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies. Mutated Fc regions and monoclonal antibodies that target FcRn are currently in clinical development...

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Bibliographic Details
Main Authors: Céline Monnet, Emilie Jacque, Christophe de Romeuf, Alexandre Fontayne, Toufik Abache, Nathalie Fournier, Gilles Dupont, Delphine Derache, Anais Engrand, Aurélie Bauduin, Aurélie Terrier, Alexander Seifert, Cécile Beghin, Alain Longue, Nicholas Masiello, Laetitia Danino, Michel Nogre, Anais Raia, Frederic Dhainaut, Louis Fauconnier, Dieudonnée Togbe, Carmen Reitinger, Falk Nimmerjahn, Wil Stevens, Sami Chtourou, Philippe Mondon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
FcRn
Fc fragment
Fc engineering
autoantibodies
autoimmune disease
immune complex (IC)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.728322/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.728322/full

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