α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation

α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation

α-Hispanolol (α-H) is a labdane diterpenoid that has been shown to induce apoptosis in several human cancer cells. However, the effect of α-H in human glioblastoma cells has not been described. In the present work, we have investigated the effects of α-H on apoptosis, migration, and invasion of huma...

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Bibliographic Details
Main Authors: Vanesa Sánchez-Martín, Lidia Jiménez-García, Sandra Herranz, Alfonso Luque, Paloma Acebo, Ángel Amesty, Ana Estévez-Braun, Beatriz de las Heras, Sonsoles Hortelano
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
α-hispanolol
apoptosis
glioblastoma
caspases
migration
matrix metalloproteinases
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00935/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00935/full

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