Vertical and horizontal dissemination of an IncC plasmid harbouring rmtB 16S rRNA methylase gene, conferring resistance to plazomicin, among invasive ST258 and ST16 KPC-producing Klebsiella pneumoniae

Vertical and horizontal dissemination of an IncC plasmid harbouring rmtB 16S rRNA methylase gene, conferring resistance to plazomicin, among invasive ST258 and ST16 KPC-producing Klebsiella pneumoniae

Objectives: Carbapenem resistance in Klebsiella pneumoniae is a major clinical challenge. Aminoglycosides remain an important asset in the current therapeutic arsenal to treat these infections. We examined aminoglycoside resistance phenotypes and genomics in a collection of 100 invasive KPC-producin...

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Bibliographic Details
Main Authors: Mélanie Roch, Roberto Sierra, Kirsty Sands, Willames M.B.S. Martins, Jacques Schrenzel, Timothy R. Walsh, Ana C. Gales, Diego O. Andrey
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
KPC-producing Klebsiella pneumoniae
16S rRNA methyltransferase
rmtB
Apramycin
Plazomicin
Aminoglycosides
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716520303209

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http://www.sciencedirect.com/science/article/pii/S2213716520303209

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