Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat

Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat

Abstract Background MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear whether and how MyD88 and related signaling pathways in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) are invo...

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Bibliographic Details
Main Authors: Fan Liu, Zhiyao Wang, Yue Qiu, Min Wei, Chunyan Li, Yikuan Xie, Le Shen, Yuguang Huang, Chao Ma
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Journal of Neuroinflammation
Subjects:
MyD88
TRIF
Dorsal root ganglion
Spinal dorsal horn
CCI
Neuropathic pain
Online Access:http://link.springer.com/article/10.1186/s12974-017-0822-9

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http://link.springer.com/article/10.1186/s12974-017-0822-9

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