A Genetic Screen for Human Genes Suppressing FUS Induced Toxicity in Yeast

A Genetic Screen for Human Genes Suppressing FUS Induced Toxicity in Yeast

FUS is a nucleic acid binding protein that, when mutated, cause a subset of familial amyotrophic lateral sclerosis (ALS). Expression of FUS in yeast recapitulates several pathological features of the disease-causing mutant proteins, including nuclear to cytoplasmic translocation, formation of cytopl...

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Bibliographic Details
Main Authors: Elliott Hayden, Shuzhen Chen, Abagail Chumley, Chenyi Xia, Quan Zhong, Shulin Ju
Format: Article
Language:English
Published: Oxford University Press 2020-06-01
Series:G3: Genes, Genomes, Genetics
Subjects:
fus
als
human gene suppressors
yeast
genetic screen
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.120.401164

Internet

http://g3journal.org/lookup/doi/10.1534/g3.120.401164

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