A Novel CD147 Inhibitor, SP-8356, Attenuates Pathological Fibrosis in Alkali-Burned Rat Cornea

A Novel CD147 Inhibitor, SP-8356, Attenuates Pathological Fibrosis in Alkali-Burned Rat Cornea

The corneal fibrotic responses to corneal damage often lead to severe corneal opacification thereby resulting in severe visual impairment or even blindness. The persistence of corneal opacity depends heavily on the activity of corneal myofibroblast. Myofibroblasts are opaque and synthesize a disorga...

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Bibliographic Details
Main Authors: Chanmin Joung, Hyojin Noh, Jeein Jung, Hwa Young Song, Hwanse Bae, Kisoo Pahk, Won-Ki Kim
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
corneal alkali burn
corneal haze
myofibroblast
alpha-smooth muscle actin
collagen type III
matrix-metalloproteinase
Online Access:https://www.mdpi.com/1422-0067/21/8/2990

Internet

https://www.mdpi.com/1422-0067/21/8/2990

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