Troponin Variants in Congenital Myopathies: How They Affect Skeletal Muscle Mechanics

Troponin Variants in Congenital Myopathies: How They Affect Skeletal Muscle Mechanics

The troponin complex is a key regulator of muscle contraction. Multiple variants in skeletal troponin encoding genes result in congenital myopathies. <i>TNNC2</i> has been implicated in a novel congenital myopathy, <i>TNNI2</i> and <i>TNNT3</i> in distal arthrogry...

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Bibliographic Details
Main Authors: Martijn van de Locht, Tamara C. Borsboom, Josine M. Winter, Coen A. C. Ottenheijm
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
troponin
skeletal muscle
sarcomere
congenital myopathy
contractility
Online Access:https://www.mdpi.com/1422-0067/22/17/9187

Internet

https://www.mdpi.com/1422-0067/22/17/9187

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