Activation of Sirtuin 3 and Maintenance of Mitochondrial Integrity by N-Acetylcysteine Protects Against Bisphenol A-Induced Kidney and Liver Toxicity in Rats

Activation of Sirtuin 3 and Maintenance of Mitochondrial Integrity by N-Acetylcysteine Protects Against Bisphenol A-Induced Kidney and Liver Toxicity in Rats

Mitochondrial impairment ensuing from oxidative imbalance is related to adverse consequences of bisphenol A (BPA), a globally utilized industrial chemical. Recent evidence reveals sirtuin 3 (SIRT3) as a key regulator of mitochondrial homeostasis; however, its role in BPA toxicity remains unidentifie...

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Bibliographic Details
Main Authors: Wachirasek Peerapanyasut, Anongporn Kobroob, Siripong Palee, Nipon Chattipakorn, Orawan Wongmekiat
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
N-acetylcysteine
bisphenol A
toxicity
oxidative stress
mitochondria
sirtuin 3
Online Access:http://www.mdpi.com/1422-0067/20/2/267

Internet

http://www.mdpi.com/1422-0067/20/2/267

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