Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons.

Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons.

The widespread distribution of the tumor suppressor PTEN in the nervous system suggests a role in a broad range of brain functions. PTEN negatively regulates the signaling pathways initiated by protein kinase B (Akt) thereby regulating signals for growth, proliferation and cell survival. Pten deleti...

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Bibliographic Details
Main Authors: Oscar Diaz-Ruiz, Agustin Zapata, Lufei Shan, YaJun Zhang, Andreas C Tomac, Nasir Malik, Fidel de la Cruz, Cristina M Bäckman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2736587?pdf=render

Internet

http://europepmc.org/articles/PMC2736587?pdf=render

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