A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms.

A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms.

<h4>Objective</h4>Cardiovascular disease is a leading cause of death worldwide. Obesity-related metabolic disorders including dyslipidemia cause impaired collateralization under ischemic conditions, thereby resulting in exacerbated cardiovascular dysfunction. Pemafibrate is a novel selec...

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Bibliographic Details
Main Authors: Hiroshi Kawanishi, Koji Ohashi, Hayato Ogawa, Naoya Otaka, Tomonobu Takikawa, Lixin Fang, Yuta Ozaki, Mikito Takefuji, Toyoaki Murohara, Noriyuki Ouchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0235362

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https://doi.org/10.1371/journal.pone.0235362

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