(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis

(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis

The myotonic dystrophies are prototypic toxic RNA gain-of-function diseases. Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are caused by different unstable, noncoding microsatellite repeat expansions – (CTG)DM1 in DMPK and (CCTG)DM2 in CNBP. Although transcription of mutant repeats into (CUG)DM1...

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Bibliographic Details
Main Authors: Vildan Betul Yenigun, Mario Sirito, Alla Amcheslavky, Tomek Czernuszewicz, Jordi Colonques-Bellmunt, Irma García-Alcover, Marzena Wojciechowska, Clare Bolduc, Zhihong Chen, Arturo López Castel, Ralf Krahe, Andreas Bergmann
Format: Article
Language:English
Published: The Company of Biologists 2017-08-01
Series:Disease Models & Mechanisms
Subjects:
Myotonic dystrophy
DM2
RNA toxicity
Drosophila
Muscleblind
Apoptosis
Online Access:http://dmm.biologists.org/content/10/8/993

Internet

http://dmm.biologists.org/content/10/8/993

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