Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation

Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation

Congenital heart defects affect ∼2% of live births and often involve malformations of the semilunar (aortic and pulmonic) valves. We previously reported a highly penetrant GATA4 p.Gly296Ser mutation in familial, congenital atrial septal defects and pulmonic valve stenosis and showed that mice harbor...

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Bibliographic Details
Main Authors: Stephanie LaHaye, Uddalak Majumdar, Jun Yasuhara, Sara N. Koenig, Adrianna Matos-Nieves, Rahul Kumar, Vidu Garg
Format: Article
Language:English
Published: The Company of Biologists 2019-06-01
Series:Disease Models & Mechanisms
Subjects:
GATA4
Valve development
Aortic valve stenosis
Genetics
Congenital heart disease
Online Access:http://dmm.biologists.org/content/12/6/dmm036764

Internet

http://dmm.biologists.org/content/12/6/dmm036764

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