Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs

Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs

Background: The archetypal DNA methyltransferase inhibitors, 5-azacytidine (AZA) and 5-aza-2'-deoxycytidine (DAC) are potent antineoplastic agents used in the treatment of mainly, blood malignancies. However, the administration of these drugs is confounded by their hydrolytic lability which dec...

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Bibliographic Details
Main Authors: Martin Hruby, Khushboo Agrawal, Olivia Policianova, Jiri Brus, Jan Skopal, Pavel Svec, Miroslav Otmar, Petr Dzubak, Petr Stepanek, Marian Hajduch
Format: Article
Language:English
Published: Palacký University Olomouc, Faculty of Medicine and Dentistry 2016-06-01
Series:Biomedical Papers
Subjects:
5-azacitidine
5-aza-2'-deoxycytidine
diclofenac
polyanhydride
microbeads
Online Access:https://biomed.papers.upol.cz/artkey/bio-201602-0007_Biodegradable_system_for_drug_delivery_of_hydrolytically_labile_azanucleoside_drugs.php

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https://biomed.papers.upol.cz/artkey/bio-201602-0007_Biodegradable_system_for_drug_delivery_of_hydrolytically_labile_azanucleoside_drugs.php

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