Lysophosphatidic acid receptor 1 (LPA1) plays critical roles in microglial activation and brain damage after transient focal cerebral ischemia

Lysophosphatidic acid receptor 1 (LPA1) plays critical roles in microglial activation and brain damage after transient focal cerebral ischemia

Abstract Background Lysophosphatidic acid receptor 1 (LPA1) is in the spotlight because its synthetic antagonist has been under clinical trials for lung fibrosis and psoriasis. Targeting LPA1 might also be a therapeutic strategy for cerebral ischemia because LPA1 triggers microglial activation, a co...

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Bibliographic Details
Main Authors: Bhakta Prasad Gaire, Arjun Sapkota, Mi-Ryoung Song, Ji Woong Choi
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Neuroinflammation
Subjects:
Lysophosphatidic acid receptor 1
AM095
shLPA1
Middle cerebral artery occlusion/reperfusion
Microglial activation
Proinflammatory cytokines
Online Access:http://link.springer.com/article/10.1186/s12974-019-1555-8

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http://link.springer.com/article/10.1186/s12974-019-1555-8

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