Amyloid Beta Peptide (Aβ<sub>1-42</sub>) Reverses the Cholinergic Control of Monocytic IL-1β Release

Amyloid Beta Peptide (Aβ<sub>1-42</sub>) Reverses the Cholinergic Control of Monocytic IL-1β Release

Amyloid-β peptide (Aβ<sub>1-42</sub>), the cleavage product of the evolutionary highly conserved amyloid precursor protein, presumably plays a pathogenic role in Alzheimer’s disease. Aβ<sub>1-42</sub> can induce the secretion of the pro-inflammatory cytokine intereukin-1β (IL...

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Bibliographic Details
Main Authors: Katrin Richter, Raymond Ogiemwonyi-Schaefer, Sigrid Wilker, Anna I. Chaveiro, Alisa Agné, Matthias Hecker, Martin Reichert, Anca-Laura Amati, Klaus-Dieter Schlüter, Ivan Manzini, Günther Schmalzing, J. Michael McIntosh, Winfried Padberg, Veronika Grau, Andreas Hecker
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Journal of Clinical Medicine
Subjects:
amyloid beta peptide
interleukin-1β
nicotinic acetylcholine receptors
monocytes
systemic inflammation
purinergic signaling
Online Access:https://www.mdpi.com/2077-0383/9/9/2887

Internet

https://www.mdpi.com/2077-0383/9/9/2887

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