Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis

Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis

Pleuropulmonary blastoma (PPB) is a very rare pediatric lung disease. It can progress from abnormal epithelial cysts to an aggressive sarcoma with poor survival. PPB is difficult to diagnose as it can be confounded with other cystic lung disorders, such as congenital pulmonary airway malformation (C...

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Bibliographic Details
Main Authors: Kim Landry-Truchon, Nicolas Houde, Mickaël Lhuillier, Louis Charron, Alice Hadchouel, Christophe Delacourt, William D. Foulkes, Louise Galmiche-Rolland, Lucie Jeannotte
Format: Article
Language:English
Published: The Company of Biologists 2020-12-01
Series:Disease Models & Mechanisms
Subjects:
yy1
pleuropulmonary blastoma
congenital pulmonary airway malformation
mir-125a-3p
emt
lung development
Online Access:http://dmm.biologists.org/content/13/12/dmm045989

Internet

http://dmm.biologists.org/content/13/12/dmm045989

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