Impact of Tenascin-C on Radiotherapy in a Novel Syngeneic Oral Squamous Cell Carcinoma Model With Spontaneous Dissemination to the Lymph Nodes

Impact of Tenascin-C on Radiotherapy in a Novel Syngeneic Oral Squamous Cell Carcinoma Model With Spontaneous Dissemination to the Lymph Nodes

Radiotherapy, the most frequent treatment of oral squamous cell carcinomas (OSCC) besides surgery is employed to kill tumor cells but, radiotherapy may also promote tumor relapse where the immune-suppressive tumor microenvironment (TME) could be instrumental. We established a novel syngeneic graftin...

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Bibliographic Details
Main Authors: Caroline Spenlé, Thomas Loustau, Hélène Burckel, Gilles Riegel, Chérine Abou Faycal, Chengbei Li, Alev Yilmaz, Luciana Petti, Fanny Steinbach, Constance Ahowesso, Camille Jost, Nicodème Paul, Raphael Carapito, Georges Noël, Fabienne Anjuère, Nathalie Salomé, Gertraud Orend
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
radiotherapy
oral squamous carcinoma
tumor microenvironment
tenascin-C
syngeneic animal model
immune suppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.636108/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.636108/full

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