The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity

Obesity is frequently associated with systemic insulin resistance, glucose intolerance, and hyperlipidemia. Impaired insulin action in muscle and paradoxical diet/insulin-dependent overproduction of hepatic lipids are important components of obesity, but their pathogenesis and inter-relationships be...

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Bibliographic Details
Main Authors: Mini P. Sajan, Mary L. Standaert, Sonali Nimal, Usha Varanasi, Tina Pastoor, Stephen Mastorides, Ursula Braun, Michael Leitges, Robert V. Farese
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Journal of Lipid Research
Subjects:
atypical protein kinase C
high fat feeding
hyperlipidemia
insulin
insulin resistance
IRS-1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520308117

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http://www.sciencedirect.com/science/article/pii/S0022227520308117

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