Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of late-onset, familial Parkinson's disease (PD), and LRRK2 variants are associated with increased risk for sporadic PD. While advanced age represents the strongest risk factor for disease development, it rem...

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Bibliographic Details
Main Authors: Megan M. Senchuk, Jeremy M. Van Raamsdonk, Darren J. Moore
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Neurobiology of Disease
Subjects:
LRRK2
Lifespan
Parkinson's disease
Neuroprotection
Neurodegeneration
Insulin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000164

Internet

http://www.sciencedirect.com/science/article/pii/S0969996121000164

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