Chronic Immune Activation and CD4+ T Cell Lymphopenia in Healthy African Individuals: Perspectives for SARS-CoV-2 Vaccine Efficacy

Chronic Immune Activation and CD4+ T Cell Lymphopenia in Healthy African Individuals: Perspectives for SARS-CoV-2 Vaccine Efficacy

Chronic immune activation has been considered as the driving force for CD4+ T cell depletion in people infected with HIV-1. Interestingly, the normal immune profile of adult HIV-negative individuals living in Africa also exhibit chronic immune activation, reminiscent of that observed in HIV-1 infect...

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Bibliographic Details
Main Authors: Dawit Wolday, Francis M. Ndungu, Gloria P. Gómez-Pérez, Tobias F. Rinke de Wit
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
Africa
chronic immune activation
SARS-CoV-2
vaccine
hyporesponsiveness
COVID-19
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.693269/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.693269/full

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