Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons

Our understanding of the molecular processes underlying Alzheimer’s disease (AD) is still limited, hindering the development of effective treatments, and highlighting the need for human-specific models. Advances in identifying components of the amyloid cascade are progressing, including the role of...

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Bibliographic Details
Main Authors: Jacqueline P. Robbins, Leo Perfect, Elena M. Ribe, Marcello Maresca, Adrià Dangla-Valls, Evangeline M. Foster, Richard Killick, Paulina Nowosiad, Matthew J. Reid, Lucia Dutan Polit, Alejo J. Nevado, Daniel Ebner, Mohammad Bohlooly-Y, Noel Buckley, Menelas N. Pangalos, Jack Price, Simon Lovestone
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
amyloid
neurodegeneration
clusterin
induced pluripotent stem cells
CRISPR/Cas
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00504/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00504/full

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