Tamoxifen and the PI3K Inhibitor: LY294002 Synergistically Induce Apoptosis and Cell Cycle Arrest in Breast Cancer MCF-7 Cells

Tamoxifen and the PI3K Inhibitor: LY294002 Synergistically Induce Apoptosis and Cell Cycle Arrest in Breast Cancer MCF-7 Cells

Breast cancer is considered as one of the most aggressive types of cancer. Acquired therapeutic resistance is the major cause of chemotherapy failure in breast cancer patients. To overcome this resistance and to improve the efficacy of treatment, drug combination is employed as a promising approach...

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Bibliographic Details
Main Authors: Mohamed E. Abdallah, Mahmoud Zaki El-Readi, Mohammed Ahmed Althubiti, Riyad Adnan Almaimani, Amar Mohamed Ismail, Shakir Idris, Bassem Refaat, Waleed Hassan Almalki, Abdullatif Taha Babakr, Mohammed H. Mukhtar, Ashraf N. Abdalla, Omer Fadul Idris
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
breast cancer
tamoxifen
LY294002
synergism
apoptosis
cell cycle
Online Access:https://www.mdpi.com/1420-3049/25/15/3355

Internet

https://www.mdpi.com/1420-3049/25/15/3355

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