Boeravinone B, A Novel Dual Inhibitor of NorA Bacterial Efflux Pump of Staphylococcus aureus and Human P-Glycoprotein, Reduces the Biofilm Formation and Intracellular Invasion of Bacteria

Boeravinone B, A Novel Dual Inhibitor of NorA Bacterial Efflux Pump of Staphylococcus aureus and Human P-Glycoprotein, Reduces the Biofilm Formation and Intracellular Invasion of Bacteria

This study elucidated the role of boeravinone B, a NorA multidrug efflux pump inhibitor, in biofilm inhibition. The effects of boeravinone B plus ciprofloxacin, a NorA substrate, were evaluated in NorA-overexpressing, wild-type, and knocked-out Staphylococcus aureus (SA-1199B, SA-1199, and SA-K1758,...

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Bibliographic Details
Main Authors: Samsher Singh, Nitin P. Kalia, Prashant Joshi, Ajay Kumar, Parduman R. Sharma, Ashok Kumar, Sandip B. Bharate, Inshad A. Khan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Microbiology
Subjects:
NorA
P-glycoprotein
biofilm
Staphylococcus aureus
efflux inhibition
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01868/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01868/full

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