Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance

Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance

Protein tyrosine phosphatase non-receptor type 2 (PTPN2) plays a pivotal role in immune homeostasis and has been associated with human autoimmune and chronic inflammatory diseases. Though PTPN2 is well-characterized in lymphocytes, little is known about its function in innate immune cells. Our findi...

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Bibliographic Details
Main Authors: Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Philipp Busenhart, Claudia Gottier, Dunja Mrdjen, Juliana Komuczki, Marcin Wawrzyniak, Silvia Lang, Kirstin Atrott, Burkhard Becher, Gerhard Rogler, Michael Scharl, Marianne R. Spalinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
PTPN2
inflammatory diseases
dendritic cells
loss of tolerance
systemic inflammation
IFNγ
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01856/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01856/full

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