Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background

Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background

Cyclooxygenase 2 (COX-2) is a key enzyme of the tumorigenesis-inflammation interface and can be induced by hypoxia. A pseudohypoxic transcriptional signature characterizes pheochromocytomas and paragangliomas (PPGLs) of the cluster I, mainly represented by tumors with mutations in von Hippel&#87...

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Bibliographic Details
Main Authors: Martin Ullrich, Susan Richter, Verena Seifert, Sandra Hauser, Bruna Calsina, Ángel M. Martínez-Montes, Marjolein ter Laak, Christian G. Ziegler, Henri Timmers, Graeme Eisenhofer, Mercedes Robledo, Jens Pietzsch
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
VHL
NF1
EPAS1
hypoxia-inducible factor
inflammation
radiosensitization
succinate dehydrogenase
mouse pheochromocytoma cells
immunohistochemistry
fluorescence imaging
Online Access:https://www.mdpi.com/2072-6694/11/6/743

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https://www.mdpi.com/2072-6694/11/6/743

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