NMR Insights into the Structure-Function Relationships in the Binding of Melanocortin Analogues to the MC1R Receptor

NMR Insights into the Structure-Function Relationships in the Binding of Melanocortin Analogues to the MC1R Receptor

Linear and cyclic analogues of the α-melanocyte stimulating hormone (α-MSH) targeting the human melanocortin receptor 1 (MC1R) are of pharmacological interest for detecting and treating melanoma. The central sequence of α-MSH (His-Phe-Arg-Trp) has been identified as being essential for receptor bind...

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Bibliographic Details
Main Authors: Maurício Morais, Héctor Zamora-Carreras, Paula D. Raposinho, Maria Cristina Oliveira, David Pantoja-Uceda, João D. G. Correia, M. Angeles Jiménez
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
α-MSH analogue
cyclic peptide
melanocortin receptor
NMR
peptide structure
Online Access:https://www.mdpi.com/1420-3049/22/7/1189

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https://www.mdpi.com/1420-3049/22/7/1189

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