Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level

Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level

<p>Abstract</p> <p>Background</p> <p>Malin is an E3-ubiquitin ligase that is mutated in Lafora disease, a fatal form of progressive myoclonus epilepsy. In order to perform its function, malin forms a functional complex with laforin, a glucan phosphatase that facilitates...

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Bibliographic Details
Main Authors: Gentry Matthew S, Bridges Travis M, Rubio Teresa, Vernia Santiago, Moreno Daniel, Romá-Mateo Carlos, Sanz Pascual
Format: Article
Language:English
Published: BMC 2011-07-01
Series:BMC Evolutionary Biology
Subjects:
AMPK
malin
TRIM32
E3 ubiquitin ligase
phylogeny
Lafora disease
Online Access:http://www.biomedcentral.com/1471-2148/11/225

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