Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells

Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells

Amyloid-β (Aβ) peptides play a crucial role in the pathogenesis of Alzheimer’s disease (AD), due to its neurotoxicity. Thus, blocking Aβ generation and aggregation in the brain has been realized as an efficient way for the prevention of AD. The natural product catalpol, isolated from Rehmannia gluti...

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Bibliographic Details
Main Authors: Zhuo Wang, Xueshi Huang, Pu Zhao, Limei Zhao, Zhan-You Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
catalpol
amyloid-β (Aβ) peptide
A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
cAMP-response element binding protein (CREB)
Swedish mutant APP overexpressed N2a cell
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00066/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2018.00066/full

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