IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery

IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery

<p>Abstract</p> <p>Background</p> <p>The transcription factor NFκB is an important mediator of cell survival and inflammation in the immune system. In the central nervous system (CNS), NFκB signaling has been implicated in regulating neuronal survival following acute pa...

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Bibliographic Details
Main Authors: Lian Hong, Shim David J, Gaddam Samson SK, Rodriguez-Rivera Jennifer, Bitner Brittany R, Pautler Robia G, Robertson Claudia S, Zheng Hui
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Molecular Neurodegeneration
Subjects:
NFκB
IκBα
Conditional knockout mice
TBI
Neuroinflammation
Cerebral blood flow
MRI
Online Access:http://www.molecularneurodegeneration.com/content/7/1/47

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http://www.molecularneurodegeneration.com/content/7/1/47

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