Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats
We investigated the potential of 4-AP (50–100 μM) to induce seizure-like events (SLEs) in combined entorhinal cortex–hippocampal slices from Sprague Dawley rats which developed spontaneous limbic seizures following kainic acid induced status epilepticus. Slices from control rats (n=8) displayed SLEs...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2008-02-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996107001970 |