Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats

Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats

We investigated the potential of 4-AP (50–100 μM) to induce seizure-like events (SLEs) in combined entorhinal cortex–hippocampal slices from Sprague Dawley rats which developed spontaneous limbic seizures following kainic acid induced status epilepticus. Slices from control rats (n=8) displayed SLEs...

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Bibliographic Details
Main Authors: Robert K. Zahn, Else A. Tolner, Christian Derst, Clemens Gruber, Rüdiger W. Veh, Uwe Heinemann
Format: Article
Language:English
Published: Elsevier 2008-02-01
Series:Neurobiology of Disease
Subjects:
Limbic epilepsy
4-aminopyridine
Voltage-gated potassium channels
Seizure susceptibility
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001970

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http://www.sciencedirect.com/science/article/pii/S0969996107001970

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