Novel Catalytically-Inactive PII Metalloproteinases from a Viperid Snake Venom with Substitutions in the Canonical Zinc-Binding Motif

Novel Catalytically-Inactive PII Metalloproteinases from a Viperid Snake Venom with Substitutions in the Canonical Zinc-Binding Motif

Snake venom metalloproteinases (SVMPs) play key biological roles in prey immobilization and digestion. The majority of these activities depend on the hydrolysis of relevant protein substrates in the tissues. Hereby, we describe several isoforms and a cDNA clone sequence, corresponding to PII SVMP ho...

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Bibliographic Details
Main Authors: Erika Camacho, Libia Sanz, Teresa Escalante, Alicia Pérez, Fabián Villalta, Bruno Lomonte, Ana Gisele C. Neves-Ferreira, Andrés Feoli, Juan J. Calvete, José María Gutiérrez, Alexandra Rucavado
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Toxins
Subjects:
snake venom metalloproteinases
PII SVMP homologues
disintegrin domain
zinc-binding motif
hemorrhagic activity
platelet aggregation
proteinase activity
Online Access:http://www.mdpi.com/2072-6651/8/10/292

Internet

http://www.mdpi.com/2072-6651/8/10/292

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