Combined Chaetocin/Trichostatin A Treatment Improves the Epigenetic Modification and Developmental Competence of Porcine Somatic Cell Nuclear Transfer Embryos

Combined Chaetocin/Trichostatin A Treatment Improves the Epigenetic Modification and Developmental Competence of Porcine Somatic Cell Nuclear Transfer Embryos

Developmental defects in somatic cell nuclear transfer (SCNT) embryos are principally attributable to incomplete epigenetic reprogramming. Small-molecule inhibitors such as histone methyltransferase inhibitors (HMTi) and histone deacetylase inhibitors (HDACi) have been used to improve reprogramming...

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Bibliographic Details
Main Authors: Pil-Soo Jeong, Hae-Jun Yang, Soo-Hyun Park, Min Ah Gwon, Ye Eun Joo, Min Ju Kim, Hyo-Gu Kang, Sanghoon Lee, Young-Ho Park, Bong-Seok Song, Sun-Uk Kim, Deog-Bon Koo, Bo-Woong Sim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
chaetocin
trichostatin A (TSA)
somatic cell nuclear transfer (SCNT)
porcine embryonic development
epigenetic reprogramming
zygotic genome activation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.709574/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.709574/full

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