Adipose tissue promotes a serum cytokine profile related to lower insulin sensitivity after chronic central leptin infusion.

Obesity is an inflammatory state characterized by an augment in circulating inflammatory factors. Leptin may modulate the synthesis of these factors by white adipose tissue decreasing insulin sensitivity. We have examined the effect of chronic central administration of leptin on circulating levels o...

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Bibliographic Details
Main Authors: Emma Burgos-Ramos, Sandra Canelles, Arancha Perianes-Cachero, Eduardo Arilla-Ferreiro, Jesús Argente, Vicente Barrios
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3462753?pdf=render